The Combating Autism Act of 2006 was a United States federal law (Pub. Law No. 109-416) which came into force on 19 December, 2006. The Act committed around one billion dollars in expenses over a period of 5 years beginning from 2007, to combat different disorders related to autism and Autism Spectrum Disorders including Asperger syndrome, Rett syndrome, Childhood Disintegrative Disorder, and PDD-NOS.

The Act was renewed in 2011 before being replaced in 2014 by the Autism CARES Act for another five years. The name change was encouraged by Ari Ne'eman and can be seen as recognition of the DSM-5.

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